The recommended daily dose of UNASYN in pediatric patients is 300 mg per kg of body weight administered via intravenous infusion in equally divided doses every 6 hours.
Unasyn (ampicillin/sulbactam) is formulated at a 2:1 ratio (3g vial = 2g ampicillin + 1g sulbactam) Strep. Group A, B, C, G. Strep. Pneumoniae. Staph. Epidermidis. ↑ Campoli-Richards DM, Brogden RN. (1987). ". Sulbactam/ampicillin: a review of its antibacterial activity, pharmacokinetic properties, and therapeutic use".
Dosing weights for acyclovir are controversial. The original package insert recommends dosing on ideal body weight in obesity. Subsequent studies suggest adjusted body should be used to reduce risk of underdosing.
The dosage of UNASYN IM/IV for most infections in children, infants and neonates is 150 mg/kg/day (corresponding to sulbactam 50 mg/kg/day and ampicillin 100 mg/kg/day). In children, infants and neonates dosing is usually every 6 or 8 hours in accordance with the usual practice for ampicillin.
The recommended daily dose of UNASYN in pediatric patients is 300 mg per kg of body weight administered via intravenous infusion in equally divided doses every 6 hours.
For IV administration, the dose can be given by slow intravenous injection over at least 10–15 minutes or can also be delivered in greater dilutions with 50–100 mL medication page for patients to search for scientific information & prescribing information about Pfizer medications in the US.
Immediately after a 15-minute infusion of 50 to 75 mg UNASYN/kg body weight, peak serum and plasma concentrations of 82 to 446 mcg ampicillin/mL and 44 to 203 mcg sulbactam/mL were obtained....
Enterococcus infection resistant to penicillin/susceptible to aminoglycosides: 3 g (2 g ampicillin + 1 g sulbactam) IV q6hr for 6 weeks if not aminoglycoside resistant; >6 weeks if aminoglycoside...
Ampicillin + Sulbactam Injection (2:1 Ratio) (Brand Name: Unasyn) Patient’s weight: Pediatric ≥1 year: 200 mg Ampicillin/kg/day IV divided Q6H (Max 2000 mg Ampicillin/dose)
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